Renal Artery Stenting for High Blood Pressure Study
The department of vascular interventional radiology at Rhode Island
Hospital is participating in a multi-center trial for patients with
high blood pressure (hypertension), which is caused by a narrowing
in the renal artery. High blood pressure is a very common disease.
In approximately 5% of people with high blood pressure, narrowing
of the renal artery is the identifiable cause. Signs that hypertension
may be caused by renal artery stenosis include young age, no family
history of high blood pressure, and high blood pressure that was
well controlled but is now difficult to manage.
Timothy Murphy, MD, is the principal investigator of this study
at Rhode Island Hospital, while Cordis Corporation, Centocor Inc.,
and Medical College of Ohio are the sponsors.
Are you eligible?
You may be eligible if you:
- Are over the age of 18 and have high blood pressure,
- Have any one of the following: congestive heart failure, poor
kidney function or angina (chest pain) or a history of any one
of the above.
About the study
The goal of this study is to determine if renal artery stenting
with or without other protection is helpful in reducing high blood
pressure. If you have a narrow artery to your kidney the narrowed
artery will be opened using a stent placed by an interventional
radiologist. The stent is a stainless steel mesh-like tube permanently
implanted to keep open the kidney artery. This stent used in this
trial is FDA (Food and Drug Administration) approved for the implantation
in the biliary tract (drainage system of the liver). You may also
qualify for additional protection of your kidney during the procedure
using a filter and medication to thin your blood.
Angioguard is a special filter, which opens up like a tiny protective
basket or umbrella allowing blood to flow through but capturing
any particles that may be dislodged during the stenting procedure
that potentially can damage the function of the kidney.
Also in this study a medication Abciximab, also called Reopro,
will be used that thins the blood. It prevents clotting and clumping
together of the blood particles
What's involved?
Participants will be screened by the vascular and interventional
radiologists to determine if there is a narrowing of the blood vessels
supplying the kidneys. The procedure will take approximately two
hours and participants wills be require to stay in the hospital
overnight. Participants are also required to come back for a 1-month
and a 6-month follow-up after his/her procedure. Participants will
be compensated for their time. A free parking voucher will be available.
For more information please contact Timothy Murphy, MD,
at 401-444-5194.
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